Objective    To determine whether rosiglitazone sodium can be used to increase insulin sensitive and improve glucose tolerance in individuals with impaired fasting glucose (IFG) on the basis of rational diet and exercise.      Methods    Totally 137 patients with IFG was divided into 2 groups randomly

lifestyle intervention group (n=68)

and the comprehensive strengthening intervention group (rosiglitazone sodium

4 mg/d

n=69). The period of observation was 6 months. The observed items included: the body mass index (BMI)

fasting plasma glucose (FPG)

postprandial 2-hour plasma glucose (2hPG)

total cholesterol (TC)

total glycerin (TG)

high density lipoprotein cholesterol (HDL-C)

low density lipoprotein cholesterol (LDL-C )

fasting insulin (FINS)

and glycohemoglobin (HbA1c) were measured. And insulin secretion index (HOMA-IS) and insulin resistance index (HOMA-IR) were calculated.       Results    After 6 months treatment

we found that FPG

2hPG

TC

TG

LDL-C

FINS and HbA1c were decreased sharply in the comprehensive strengthening intervention group compared with the values of these parameters before treatment (P0.05). After 6 months’ rational diet and exercise

the lifestyle intervention group had little declined BMI

WHR

TC

TG

LDL-C

FPG

2hPG

FINS and HbA1c in compared with before intervention (P0.05). There was no any adverse effect or side effect observed.     Conclusion    It is recommendable to administer rosiglitazone sodium to the patients with IFG on the basis of rational diet and exercise.