Zhu Jin,Jin Xianqing.Expression of Bcl-2 and calretinin in dysplasia enteric ganglion cells of hirschsprung patients[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(01):60-62.
Zhu Jin,Jin Xianqing.Expression of Bcl-2 and calretinin in dysplasia enteric ganglion cells of hirschsprung patients[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(01):60-62.DOI:
Objective To explore the expression of Bcl-2 and calretinin (CR)in enteric ganglion cells in different developmental conditions and its significance. Methods The immunohistochemical staining was carried out to detect the expression of Bcl-2 and CR in enteric ganglion cells at different intestinal segments from tissue samples of 40 hirschsprung disease (HD) cases (age
26 d to 12 years old)
10 Hirschsprung’s allied disease (HAD) cases and 10 normal controls. Results In immature ganglion cells
there was a strong expression of Bcl-2
and no positive to or poor expression of CR. In mature ganglion cells
there was a strong expression of CR but no positive Bcl-2 staining. Conclusion The specific expression of Bcl-2 and CR may play an essential role in judging if the ganglion cells are mature. Bcl-2 might be of importance in the maintenance and restore of the fuction of enteric immature ganglion cells.