Objective   To investigate the regulative role of N-Acetyl-D-glucosamine (GlcNAc) on the stressed mice macrophages function.    Methods   The stressed mice model was established by electric footshock method. The mice were divided into 5 groups: normal control group

stressed mice model group

low dose GlcNAc treatment group (0.25 ml 15%GlcNAc)

medium-dose GlcNAc treatment group (0.5 ml 15%GlcNAc) and high-dose GlcNAc treatment group (1 ml 15%GlcNAc). GlcNAc was intragastrically injected to corresponding mice 2 h before the electrical stimulation. Peritoneal macrophage (PMφ) phagocytosis capability was detected by phagocytosis saccharomycete assay

and PMφ energy metabolism was detected by MTT assay.    Results   Compared with normal control group

stressed mice PMφ phagocytosis capability was significantly lower (P0.01)

and energy metabolism significantly reduced (P0.01). High-dose GlcNAc and medium-dose GlcNAc enhanced effectively PMφ phagocytosis capability and improved the energy metabolism.    Conclusion   GlcNAc has regulative role on the dysfunction of stressed mice PMφ.