血管内皮生长因子和基质金属蛋白酶-9在前列腺癌中的表达及其相互关系

王钦文; 刁鑫伟; 陈正堂; 叶明福; 许建平; 王亚丽

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血管内皮生长因子和基质金属蛋白酶-9在前列腺癌中的表达及其相互关系

论著 | 更新时间：2026-01-09

- 血管内皮生长因子和基质金属蛋白酶-9在前列腺癌中的表达及其相互关系
- Clinical significance of expressions of vascular endothelial growth factor and matrix metalloproteinase-9 in prostate carcinoma
- 陆军军医大学学报 2009年31卷第19期页码：1859-1861
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  中图分类号： R341;R730.23;R737.25
- 纸质出版：2009
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王钦文,刁鑫伟,陈正堂,叶明福,许建平,王亚丽.血管内皮生长因子和基质金属蛋白酶-9在前列腺癌中的表达及其相互关系[J].陆军军医大学学报(原第三军医大学学报),2009,31(19):1859-1861.

　WANG Qin-wen,DIAO Xin-wei,CHEN Zheng-tang,YE Ming-fu,XU Jian-ping,WANG Ya-li.Clinical significance of expressions of vascular endothelial growth factor and matrix metalloproteinase-9 in prostate carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(19):1859-1861.
王钦文,刁鑫伟,陈正堂,叶明福,许建平,王亚丽.血管内皮生长因子和基质金属蛋白酶-9在前列腺癌中的表达及其相互关系[J].陆军军医大学学报(原第三军医大学学报),2009,31(19):1859-1861. DOI：

　WANG Qin-wen,DIAO Xin-wei,CHEN Zheng-tang,YE Ming-fu,XU Jian-ping,WANG Ya-li.Clinical significance of expressions of vascular endothelial growth factor and matrix metalloproteinase-9 in prostate carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(19):1859-1861. DOI：

摘要

目的分析血管内皮生长因子（vascular endothelial growth factor

VEGF）和基质金属蛋白酶-9（matrix metalloproteinase-9，MMP-9）在前列腺癌中的表达及其相互关系。方法应用免疫组织化学方法，检测148例前列腺癌（prostate cancer ，PCa）组织中和10例前列腺增生（benign prostatic hyperplasia ，BPH）组织中VEGF和MMP-9的表达。结果前列腺癌组织中VEGF和MMP-9的高表达率分别为66.2%、39.2%，显著高于前列腺增生组（P0.05）。VEGF和MMP-9的表达与前列腺癌的分化程度及转移有关（P0.05），与患者的年龄及雄激素受体水平（AR）无关（P0.05）。且VEGF、MMP-9在前列腺癌中的表达具有相关性。结论 VEGF和MMP-9的表达与前列腺癌的发展密切相关，并对前列腺癌的预后判定有一定的意义。

Abstract

Objective To explore the relationship between the expressions of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in prostate cancer. Methods The expression of VEGF and MMP-9 in 148 samples of pathologically verified human prostate cancer (PCa) and 10 samples of benign prostatic hyperplasia (BPH) were detected by immunohistochemical staining. Results VEGF was overexpressed in 98 of 148 tumor tissues (66.2%) and MMP-9 was overexpressed in 58 of 148 tumor tissues (39.2%). Both of them were significantly higher than those in BPH (P0.05). The expression of VEGF and MMP-9 was correlated with metastasis and differentiation (P0.05)

but it was not related to the androgen receptor (AR) level and the age of patients (P0.05). But the expression of VEGF was correlated with that of MMP-9. Conclusion The expressions of VEGF and MMP-9 are closely associated with the development of prostate cancer. Therefore VEGF and MMP-9 may be clinically useful as predictor of patients’ survival.

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