Objective    To explore the damage of ultrasound (US)-induced microbubble (MB) cavitation on the prostate in dogs.     Methods    A total of 15 dogs were randomly divided into 3 groups

US+MB group

simple US group and MB group. After abdominal opening to expose the prostates

the dogs of US+MB group received an intravenous injection of self-made MB 0.1 ml/kg and a pulsed focused ultrasound radiation  for 10 min at the same time. The animals of simple US group were given normal saline injection and the radiation

while those of the MB group were injected with MB at the same dose but no ultrasound radiation. The prostates was removed immediately after radiation for gloss observation

light and electron microscopy.     Results    Microvessle rupture

hemorrhage and hematoma in the prostate were found in the US+MB group. And swollen organelles

broken intercellular bridge and infiltrated erythrocyte were observed too.     Conclusion    Ultrasound-induced MB cavitation causes obvious mechanical damage in the prostate tissue of dogs.