Objective   To analyze the drug therapeutic regimen and duration of the chemotherapy in the spinal tuberculosis in order to determine the best therapeutic regimen and duration of the spinal anti-tuberculosis.    Methods   The medication plan and duration of 890 hospitalized patients with spinal tuberculosis in our hospital from January 2001 to December 2008 were retrospectively investigated. We collected the plan of the initial treatment

retreatment

recrudescence and drug resistance. We also studied the individuation therapeutic regimen of the patients with tuberculosis at other parts or complications. On the basis of these data

we analyzed the interferential appearance that the anti-tuberculosis drug acted on different onsets

manifestations and operations.    Results   In 890 patients of spinal tuberculosis

596 cases (67%) were initial treatment

294 (33%) were retreatment

recur cases were 110 (12.3%)

drug resistance cases were 74(8.3%)

and those complicated with tuberculosis in other parts were 273 (30.7%). The main chemotherapeutic regimen was the usual tetragenous protocol (H12/R12/E9/Z5/S3). The retreatment cases were given second-line drugs such as levofloxacin. The drug resistance cases were also given second-line drugs and intravenous infusion. According to the anti-tubercle bacillus spectrum

individuation treatments were adopted

and the plan was changed in time. The medication duration continued for 9-36 months. All the 890 patients were cured.    Conclusion   For the treatment of spinal tuberculosis

it is significance to make a efficient and standardized anti-tuberculosis chemotherapy.