Objective   To investigate the clinical significance of urinary albumin（ALB）

Tamn-Horsfal protein (THP)

immunoglobulin G（IgG） and urinary β

2

-microgiobulin（β

2

MG） in the diagnosis of early renal impairment in autoimmune thyroid disease.    Methods   Concentrations of urinary ALB

THP

IgG and β

2

MG were measured in 33 healthy controls

35 patients with simple goiter and 93 patients with autoimmune thyroid disease-related nephropathy(include 45 patients

with hyperthyroidism and 48 patients with chronic lymphocytic thyroiditis).    Results   The urinary IgG levels in patients with chronic lymphocytic thyroiditis were significantly increased compared with both healthy controls and the patients with simple goiter（P0.05）

while the urinary ALB concentrations in patients with chronic lymphocytic thyroiditis was higher than in patients with simple goiter and in the healthy controls（P0.05）. Compared with healthy controls

the patients with autoimmune thyroid disease nephropathy and simple goiter had a significant higher level of β

2

MG（P0.05）and showed a trend towards increased urinary THP（P0.05）.    Conclusion   Urinary ALB

THP

IgG and β

2

MG are valuable markersin the diagnosis of early renal impairment caused by autoimmune thyroid disease.