Objective   To compare the resuscitation effect of lactated Ringer’s solution (LR) combined with hydroxyethyl starch (HES)

whole blood or red blood cells on hemorrhagic shock rats.    Methods   SD rats (n=24) were inflicted with a sharp resection of 75% of the tail to initiate the hemorrhage. When the blood pressure (BP) was decreased to 40 mmHg

LR solution was infused to the rats for 1 h. Then the animals were randomly divided into 3 groups

LR+HES (group Ⅰ)

LR+HES+auto-whole blood (group  Ⅱ)

and LR+HES+auto-red blood cells gr

oups (group   Ⅲ)

and received the corresponding infusion respectively for 2 h when the BP was increased to 80 mmHg. The blood samples were collected before shock

1 h after shock and 2 h after resuscitation. Hematologic and hemodynamics parameters

such as blood cell count

heamoglobin

hematocrit

platelet count

heart rate

BP

survival time

left intraventricular systolic pressure (LVSP)

maximal change rate of left intraventricular pressure (±dp/dt

max

)

were measured and recorded.    Results   Hematologic parameters of each group had significant difference in 1 h after shock compared with 2 h after resuscitation

and the 2 time points compared with before shock. Those of group  Ⅱ and group   Ⅲ   were significantly higher than those of group  Ⅰ. In every group

the parameters at the time of 2 h after resuscitation had significant difference to those at 1 h after shock. Group Ⅱ and group   Ⅲ    had a significantly longer survival time compared with group Ⅰ. HR

LVSP and ±dp/dt

max

  in each group　at 1 h after shock and 2 h after resuscitation were significantly decreased compared with before shock. Those of group Ⅱ and group    Ⅲ   were significantly higher compared with group   Ⅰ; those of each group in 2 h after resuscitation were markedly increased compared with 1 h after shock.    Conclusion   LR solution plus HES has efficient effect on the resuscitation of hemorrhagic shock rats to maintain normovolemia

and the infusion of auto-red blood cells is helpful to correct anemia. Plasma-poor red cell concentrates is safe and causes no abnormal phenomena of blood clotting.