乳酸-羟基乙酸共聚物缓释纳米微球的制备及体外释药评价

赵先英; 刘毅敏; 肖湘; 粟永萍; 贺建; 李明春; 张肖莎

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乳酸-羟基乙酸共聚物缓释纳米微球的制备及体外释药评价

论著 | 更新时间：2026-01-09

- 乳酸-羟基乙酸共聚物缓释纳米微球的制备及体外释药评价
- Preparation of LIDA-PLGA slow release nanospheres and evaluation of the release properties in vitro
- 陆军军医大学学报 2009年31卷第12期页码：1155-1157
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  中图分类号： {R914.2};R944.9;R96
- 纸质出版：2009
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赵先英,刘毅敏,肖湘,粟永萍,贺建,李明春,张肖莎.乳酸-羟基乙酸共聚物缓释纳米微球的制备及体外释药评价[J].陆军军医大学学报(原第三军医大学学报),2009,31(12):1155-1157.

　ZHAO Xian-ying,LIU Yi-min,XIAO Xiang,SU Yong-ping,HE Jian,LI Ming-chun,ZHANG Xiao-sha.Preparation of LIDA-PLGA slow release nanospheres and evaluation of the release properties in vitro[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(12):1155-1157.
赵先英,刘毅敏,肖湘,粟永萍,贺建,李明春,张肖莎.乳酸-羟基乙酸共聚物缓释纳米微球的制备及体外释药评价[J].陆军军医大学学报(原第三军医大学学报),2009,31(12):1155-1157. DOI：

　ZHAO Xian-ying,LIU Yi-min,XIAO Xiang,SU Yong-ping,HE Jian,LI Ming-chun,ZHANG Xiao-sha.Preparation of LIDA-PLGA slow release nanospheres and evaluation of the release properties in vitro[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(12):1155-1157. DOI：

摘要

目的以乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid)，PLGA

]

为材料，制备缓释局麻药利多卡因（Lidocaine，LID）-PLGA长效缓释微球。方法采用乳化溶媒挥发法制备微球；采用紫外分光光度法测定微球载药量、包封率和体外药物释放。结果纳米微球形态光滑圆整，球体大小均匀，微球粒径为（174.5±15.2）nm，微球载药量和包封率分别为12.48%和54.30%，微球体外释放符合Higuchi方程，半衰期t

1/2

=3.45 d。结论 LID-PLGA纳米微球具有明显缓释作用。

Abstract

Objective To prepare LID-PLGA nanospheres (LID-PLGA-Ns) with poly(lactic-co-glycolic acid) (PLGA) for the study of the release properties in vitro. Methods The nanospheres were prepared by the solvent evaporation method. The drug-loading

encapsulation efficiency and release in vitro were determined by ultraviolet-visible spectrophotometry. Results The prepared LID-PLGA-Ns were even and uniform spheres with mean particle size of (174.5±15.2)nm in diameter. The drug loading and encapsulation efficiency were 12.48% and 34.30%

respectively. The in vitro release profile of nanospheres was found to agree with Higuchi equation

with t

1/2

=3.45 d . Conclusion The prepared nanospheres loaded with lidocaine are of slow-release function in vitro.

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