Objective   To synthesize 24-methylenecholestan-3β

5α

6β-triol

a compound same as a marine natural product

.    Methods   The target molecule was synthesized in 7 steps using hyodeoxycholic acid as the starting material

3β-(tetrahydropyran-2-yloxy)-cholest-5-ene-24-ketone as the key intermediate and isopropylation in Grignard reagents as the key step.    Results   The target molecule was synthesized in a total yield of 53% and confirmed by mass spectrometry (MS)

proton magnetic resonance spectroscopy (

1

HNMR)

carbon magnetic resonance spectroscopy

(

13

CNMR) and infrared spectroscopy (IR).    Conclusion   Our method to synthesize 24-methylene-cholestan-3β

5α

6β-triol is characterized by easily available and cheap starting material

short synthetic route

high yield and atom-economic.