Objective   To design and synthesize an antitubercular compound

24-ketoarguesterol.    Methods   The target compound was synthesized via 8 steps

including methyl esterification

grignard isopropylation

deportation

etc.

using hyodeoxycholic acid as the starting material. 3β-tert-butyldimethylsilyoxyl-5β-hydroxyl-6β-di-me-thoxylmethyl-24-keto-B-norcholanate was the key intermediate and grignard isopropylation as the key step.    Results   The target compound was synthesized in a total yield of 42% and identified by mass spectrometry (MS)

proton magnetic resonance spectroscopy (

1

HNMR)

carbon magnetic resonance spectroscopy

(

13

CNMR) and infrared spectroscopy (IR).    Conclusion   The synthetic route is characterized by atomic economy and high efficiency and laid the foundation for development of novel  antituberculous drugs.