Objective   To investigate the beneficial effect of arginine vasopressin (AVP) on uncontrolled hemorrhagic shock when used in the stage of definitive treatment in rats.   Methods   SD rats were used to make uncontrolled hemorrhagic shock by resection of the splenic parenchyma and one of the branches of splenic artery. Experiments were conducted by observing the resuscitative effects of Lactate

d Ringer’s (LR)

AVP (0.4 or 0.04 U/kg) on shock rats at the decisive treatment stage to search for the ideal treatment measures.   Results   AVP at the concentration of 0.4 U/kg and 0.04 U/kg can significantly improve the hemodynamic parameters including left intraventricular systolic pressure (LVSP)

the maximal change rate of left intraventricular pressure (±dp/dt

max

)

and the 24-h survival rate of uncontrolled hemorrhagic shock rats in stage of definitive phase (P0.05) as compared with those in LR group.   Conclusion   AVP may be beneficial for the treatment of uncontrolled hemorrhagic shock.