Objective    To explore the expressions of endothelial growth factor-D (VEGF-D) and urokinase-type plasminogen activator (uPA) in colon carcinoma and to reveal their correlation with the tumor invasion and metastasis.     Methods    The expressions of VEGF-D and uPA were detected by immunohistochemistry and Western blotting in 30 specimens of colon carcinoma and 30 specimens of normal neighbouring colon tissue 5 cm away from the lesions.     Results    The expressions of VEGF-D and uPA mostly located in endochylema

less in nucleus

of both tumor tissue and normal tissue

and they were significantly higher in tumor tissue than normal tissue (P0.01). The expressions of VEGF-D or uPA were significantly higher in Dukes’ stage C+D than in Dukes’ stage A+B (P0.01)

in the cases with lymph node metastasis or distant metastasis than those without metastasis (P0.05

P0.01)

and in poorly differentiated tumor than in well-differentiated tumor (P0.05).      Conclusion    The overexpression of VEGF-D and uPA in colon carcinoma may play an important part in the tumorigenesis and progression of colon carcinoma.