Objective    To investigate the feature of angiogenesis in C6 brain gliomas by 64-slice MSCT perfusion imaging.     Methods    C6 cells were planted into 40 Wistar rats brain via stereotaxic apparatus. Ten rats were randomly selected at the time periods of 5-9 days

10-14 days

15-19 days after cell transplantation to do CT perfusion for the changes of functional cerebral parameters. The data were transferred to the workstation to establish the time-signal curve and the perfusion maps.     Results    The values of cerebral blood flow (CBF) and cerebral blood volume (CBV) increased at 5-9 days

peaked at 10-14 days and maintained stably in a high level. The value of permeability surface (PS) in glioma rats increased at all time periods. No significant difference was found in mean transit time (MTT) of glioma at each time period.     Conclusion    Angiogenesis in the glioma transplanted rats increases in 15 days. The changes of angiogenesis with time must be considered as the factor for therapeutic effect.