Objective    To establish a Wistar rat model of C6 brain glioma and explore the growth pattern in C6 brain glioma rats by MRI and CT perfusion (CTP) imaging.     Methods    Rat model of brain glioma was established by implanting C6 cells into 40 adult Wistar rats with stereotactic technique. CTP

MRI and pathologic examination were performed in 10 implanted rats randomly sampled at the time periods of 5-9 d

10-14 d

15-19 d after tumor implantation. The grow

th pattern of C6 brain glioma in rats was observed and the correlation between imagings and histopathologic results was evaluated.     Results    There had significant difference at 15-19 d (t=3.131

P0.01; t=2.566

P0.05) between CTP

MRI and histopathologic results

but no significant difference (P0.05) between CTP and MRI; and no significant difference (P0.05) at 5-9 d

10-14 d. Pearson linear correlation analysis revealed a significant positive correlation among the growth of tumor shown on CTP and MRI and by pathologic methods (r=0.998

0.998

1.000; P0.01). Regression analysis indicated the tumor volume was in exponential growth with time (r

patho

=0.990

r

CTP

=0.987

r

MRI

=0.990

P0.01).     Conclusion    Imaging observation in vivo can accurately reflect the practical tumor volume

and is suitable for the growth pattern of tumor in animal model and to evaluate the efficiency of experimental therapy.