Objective    To study the oxidative stress in diabetic rat pancreas

and the changes of islet function after intervention of Fosinopril.     Methods    Wistar rats were randomly divided into control group

diabetes group and Fosinopril treated group. The diabetes was induced by feeding the rats from diabetes group and Fosinopril group with high fat diet for 3 weeks and then once intraperitoneal injection of STZ (35 mg/kg)

while additionally Fosinopril (5 mg/kg) was given to the diabetic rats in Fosinopril treated group. Blood glucose

body weight

nitrotyrosine levels in pancreatic tissues were detected and the histopathologic changes of pancreatic tissues were observed.     Results    Nitrotyrosine content was significantly higher in diabetes group than that in control group (P0.01). Nitrotyrosine content and the level of oxidative stress were significantly decreased in Fosinopril treated group compared with those in diabetes group (P0.05).     Conclusion    Nitrotyrosine content is abnormal in diabetic rats

and Fosinopril can significantly inhibit the oxidative stress in pancreas.