Objective    To establish an experimental animal model which can be used to evaluate the antishock effects of an oxygen-carrying shock resuscitation fluid.     Methods    SD rats were used to make hemorrhagic shock model by 35%

45%

55% and 65% hemorrhage respectively under anesthesia. Effects of Lactated Ringer’s solution (LR) and whole blood on mean arterial blood pressure (MAP)

left intraventricular systolic pressure (LVSP)

the maximal change rate of left intraventricular pressure (±dp/dt

max

) in those 4 types of hemorrhagic shock rats were observed. Blood gas and 24-hour survival rate were also observed.     Results    For rats with 35% hemorrhagic shock

LR and blood infusion recovered MAP to 90-100 mmHg

but had no significantly difference in hemodynamic parameters and blood gas. In 45% and 55% hemorrhagic shock

blood infusion improved hemodynamic parameters and blood gas significantly better than LR infusion. The 24-hour survival rate in blood treatment group were higher than LR group. Animal in 65% hemorrhagic group died soon after hemorrhage

and could not be used as the evaluation animal.     Conclusion    Rats with 55% hemorrhagic shock is an ideal experimental model to evaluate the antishock effect of oxygen-carrying shock resuscitation fluid.