PTEN、P27、TGF-β<sub>1</sub>在宫颈腺癌组织中的表达及临床意义

杨君; 唐良萏; 王彬

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PTEN、P27、TGF-β₁在宫颈腺癌组织中的表达及临床意义

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- PTEN、P27、TGF-β₁在宫颈腺癌组织中的表达及临床意义
- Expressions of PTEN, P27 and TGF-β₁ in cervical adenocarcinoma and their clinical significance
- 陆军军医大学学报 2009年31卷第2期页码：148-151
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  中图分类号： R730.23;R730.43;R737.33
- 纸质出版：2009
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杨君,唐良萏,王彬.PTEN、P27、TGF-β1在宫颈腺癌组织中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(02):148-151.

　YANG Jun,TANG Liang-dan,WANG Bin.Expressions of PTEN, P27 and TGF-β1 in cervical adenocarcinoma and their clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(02):148-151.
杨君,唐良萏,王彬.PTEN、P27、TGF-β1在宫颈腺癌组织中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2009,31(02):148-151. DOI：

　YANG Jun,TANG Liang-dan,WANG Bin.Expressions of PTEN, P27 and TGF-β1 in cervical adenocarcinoma and their clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(02):148-151. DOI：

摘要

目的探讨抑癌基因PTEN、P27及转化生长因子β

（transforming growth factor-β

TGF-β

）在宫颈腺癌中的表达及三者之间的相关性。方法采用免疫组化S-P法检测43例宫颈腺癌，18例正常宫颈组织石蜡切片中PTEN、P27及TGF-β

的表达。结果 43例宫颈腺癌组织PTEN、P27阳性表达率分别为62.79%、55.81%，均明显低于正常宫颈组织（P0.05）。PTEN、P27的阳性表达率在临床分期为 Ⅱ

及以上宫颈腺癌组织中明显降低（P0.01），且在高分化腺癌组织中呈高表达。TGF-β

的阳性表达率在正常宫颈组（11.11%）与宫颈腺癌组（5.88%）之间差异无统计学意义（P0.05）

TGF-β

蛋白表达与宫颈腺癌的临床及病理特征无统计学差异(P0.05)。宫颈腺癌组织中PTEN与P27蛋白表达呈正相关（r

=0.808，P0.01），TGF-β

表达与PTEN、P27无关。结论 PTEN、P27对宫颈腺癌预后判断有一定参考价值。宫颈腺癌的发生及进展可能与TGF-β

蛋白表达无关。

Abstract

Objective To examine the expressions of phosphatase and tension homologue deleted on chrom osome10 (PTEN)

P27 and TGF-β

in cervical adenocarcinoma

and study their clinical significance and their correlativity. Methods Forty-three cervical adenocarcinomas were compared with 18 normal endocervical controls by immunohistochemical analysis of PTEN

P27 and TGF-β

. Results PTEN and P27 exhibited higher positive

rates in cervical adenocarcinomas (62.79% and 55.81%) than those in normal endocervical controls (88.89% and 94.44%) (P0.05). The levels of PTEN or P27 expression in cervical adenocarcinomas decreased with the increasing of clinical stage (P0.01)

whereas positive staining of PTEN or P27 in well-differentiated carcinoma tissues was significantly stronger than that in moderately- or poorly-differentiated carcinoma tissues. No significant difference was between the positive rate of TGF-β

in normal endocervical controls (11.11%) and that in cervical adenocarcinomas (5.88%) (P0.05). No relationship was found between the expression of TGF-β

in cervical adenocarcinoma and clinical or pathological features (P0.05). The expression of PTEN was positively correlated to P27 in cervical adenocarcinoma. No obvious relationship of TGF-β

with PTEN or P27 was found. Conclusion PTEN and P27 are of value in the prognosis of cervical adenocarcinoma. TGF-β

may not contribute to carcinogenesis and development of cervical adenocarcinoma.

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PTEN、P27、TGF-β1在宫颈腺癌组织中的表达及临床意义

Expressions of PTEN, P27 and TGF-β1 in cervical adenocarcinoma and their clinical significance

DOI：

摘要

Abstract

关键词

Keywords

references

PTEN、P27、TGF-β₁在宫颈腺癌组织中的表达及临床意义

Expressions of PTEN, P27 and TGF-β₁ in cervical adenocarcinoma and their clinical significance