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纸质出版:2008
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刘卓灵,龚水根,张伟国,王毅,胡伟,冉启胜,谭勇.胃肿瘤多层螺旋CT灌注成像参数的临床价值初探[J].陆军军医大学学报(原第三军医大学学报),2008,30(20):1922-1925.
LIU Zhuo-ling,GONG Shui-gen,ZHANG Wei-guo,WANG Yi,HU Wei,RAN Qi-sheng,TAN Yong.Clinical value of parameters from perfusion imaging of stomach tumor by 64 MSCT[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(20):1922-1925.
刘卓灵,龚水根,张伟国,王毅,胡伟,冉启胜,谭勇.胃肿瘤多层螺旋CT灌注成像参数的临床价值初探[J].陆军军医大学学报(原第三军医大学学报),2008,30(20):1922-1925. DOI:
LIU Zhuo-ling,GONG Shui-gen,ZHANG Wei-guo,WANG Yi,HU Wei,RAN Qi-sheng,TAN Yong.Clinical value of parameters from perfusion imaging of stomach tumor by 64 MSCT[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(20):1922-1925. DOI:
目的 比较不同病理类型胃肿瘤多层螺旋CT(multi-slice computed tomography, MSCT)灌注成像参数的差异
探讨其临床应用价值。 方法 运用64 MSCT对34例经胃镜及术后病理证实的胃肿瘤患者行灌注成像扫描
根据病理结果将34例患者分成3组:胃癌组(n=23)、胃淋巴瘤组(n=4)和胃间质瘤组(n=7) 。计算癌肿感兴趣区的灌注参数:血流量(blood flow
BF) 、血容量(blood volume
BV)、平均通过时间(mean transit time
MTT)和表面通透性(permeability surface
PS) 。并对各灌注参数值进行统计分析。 结果 胃癌组BF、BV、MTT和PS平均值分别为(69.36±49.62) ml/(100 g·min)、(5.78±2.58)ml/100 g、(8.64±6.02)s和(38.60±24.46)ml/(100 g·min) ; 胃淋巴瘤组为(23.60±14.87)ml/(100 g·min) 、(2.64±0.58)ml/100 g、(10.68±5.33)s和(22.51±15.99)ml/(100 g·min)
胃间质瘤组为(50.66±30.92)ml/(100 g·min)、(4.95±1.61)ml/100 g、(11.23±8.09)s和(10.05±8.96)ml/(100 g·min)。其中胃癌组与淋巴瘤组BF、BV和PS平均值
胃癌组与胃间质瘤组PS平均值以及胃淋巴瘤组与胃间质瘤组BV平均值之间的差异具有非常显著的统计学意义(P0.01);胃淋巴瘤组与胃间质瘤组BF和PS平均值有显著统计学意义(P0.05);胃癌组与胃间质瘤组BF平均值及胃癌组、胃淋巴瘤组和胃间质瘤组MTT平均值的差异无统计学意义(P0.05)。 结论 64 MSCT灌注成像能从血流动力学方面为胃肿瘤提供定量信息
不同病理类型的胃肿瘤灌注参数值在总体上有显著差异
具有一定的临床意义。
Objective To compare the difference of CT perfusion imaging parameters for stomach tumors of various pathologic types and explore their clinical application value. Methods Thirty-four patients with stomach tumor
confirmed by gastroscopic examination and postoperative pathologic biopsy
were scanned with a 64 MSCT scanner using perfusion technique. Thirty-four patients were classified into three groups according to the pathological findings: cancer (n=23)
lymphoma (n=4)
interstitialoma (n=7). Their CT hemodynamic parameters including blood flow (BF)
blood volume (BV)
mean transit time (MTT) and permeability surface (PS)
were measured in regions of interest and statistically analyzed. Results The mean BF
BV
MTT and PS of stomach cancer groups were (69.36±49.62)ml/(100 g·min)
(5.78±2.58)ml/100 g
(8.64±6.02)s
(38.60±24.46)ml/(100 g·min); of stomach lymphoma groups were (23.60±14.87)ml/(100 g·min)
(2.64±0.58)ml/100 g
(10.68±5.33)s
(22.51±15.99)ml/(100g·min); of stomach interstitialoma groups were (50.66±30.92)ml/(100 g·min)
(4.95±1.61)ml/100g
(11.23±8.09)s
(10.05±8.96)ml/(100 g·min)
respectively. There were very significant statistical differences in mean BF
BV and PS between stomach cancer groups and stomach lymphoma groups
in mean PS between stomach cancer groups and stomach interstitialoma groups
in mean BV between stomach lymphoma and stomach interstitialoma groups (P0.01); there were significant statistical differences in mean BF and PS between stomach lymphoma and stomach interstitialoma groups (P0.05); no significant statistical differences were found in mean BF between stomach cancer and stomach interstitialoma as well as the mean MTT among the three groups (P0.05). Conclusion 64 MSCT perfusion imaging technique can provide quantitative information about stomach tumor. CT perfusion imaging parameters of stomach tumors are of significant statistical differences in different pathologic types and are helpful in clinic diagnosis of stomach tumors.
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