Objective  To observe the impact of transplant nephrectomy on panel reactive antibodies and a secondary renal transplantation.   Methods  Panel reactive antibodies in 15 patients with a failed renal transplant admitted in our hospital between 2004 to 2007 were measured before transplantation

before and 1 month

6 months

12 months after transplant nephrectomy

and the pathological changes were observed after transplant nephrectomy.   Results  Panel reactive antibodies was increasing after renal transplantation

and reached the highest level one month after transplant nephrectomy

then grandually got down. New HLA allosensitization sites were discovered after transplant nephrectomy. Large amount of C4d was stained in failed transplant.   Conclusion  Serum PRA increased after transplant nephrectomy. New HLA allosensitization sites were found

which may be useful in HLA matching.