Objective    To study the pathological changes

clinical features and CT manifestation of nonalcoholic fatty liver disease (NAFLD)．    Methods    The relationships among histopathologic features of the liver

serum biochemical parameters and other clinical data of 45 NAFLD patients were studied. CT

examinations were performed in 16 patients.     Results    According to liver fatty degeneration grading

12 cases were classified to F

0

19 cases to F

1

13 cases to F

2

and 1 case to F

3

. As to the grading of inflammatory activities

9 cases were G

0

14 G

1

17 G

2

and 5 G

3

. As to the grading of fibrosis

11 cases were S

0

9 S

1

16 S

2

and 5 S

3

. The hepatocyte steatosis was correlated to waistline (r=0.357

P=0.028)

waist-to-hip ratio (r=0.463

P=0.001 6)

and total cholesterol (r=0.484

P=0.004). The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) showed no significant difference among each grade of liver inflammatory activity. The grade of hepatic steatosis was negatively correlated with liver value of CT. The liver-to-spleen ratios were not significantly different among F

0

F

1

and F

2

.     Conclusion    In NAFLD patients

with the increment of waistline

waist-to-hip ratio and TC

the steatosis gets worse. The levels of ALT and AST do not parallel with the hepatic steatosis. The degree of steatosis is negatively correlated with the liver value of CT

but the liver-to-spleen ratio does not reflect the grade of the liver degeneration.