Objective    To evaluate the relationship between perfusion image of multi-slice spiral CT（MSCT） and microvessel density（MVD）of lung solitary nodule or mass.     Methods    A total of 33 patients with lung solitary nodule or mass underwent MSCT perfusion scanning by GE Light-Speed ultra 16 CT scanner before CT-guided percutaneous pulmonary biopsy or operation

and HE staining and immunohistochemical examination of the specimen were performed. CT perfusion parameters and MVD of the 33 cases were compared.     Results    Among all 33 cases

there were 20 cases of peripheral lung cancer

5 cases of acute inflammation and 8 cases of benign solitary nodule or mass. MVD of malignant and inflammatory cases was significantly higher than that of the benign ones（P0.01）

while no statistically significant difference was found between malignant and inflammatory cases（P0.05）. BF

BV and PS except MTT were correlated with MVD

respectively（P0.01）.     Conclusion    BF

BV and PS were positively correlated with MVD in lung solitary nodule or mass. MSCT perfusion imaging provides an effective method to assess MVD of lung cancer in vivo.