Objective    To explore the prevalence of drug-resistant tuberculosis in the past 3 years in Chongqing. and found basis for prevention

control and treatment drug-resistant tuberculosis.     Methods    Cases diagnosed as pulmonary tuberculosis were collected from Chongqing Chest Hospital and Institute of Tuberculosis Prevention and Treatment of Chongqing from June 2003 to June 2006. Proportion method was used to test the drug susceptibility of isoniazide (INH)

rifampicin (RFP)

streptomycin (SM) and ethambutol (EMB).      Results    All 1 089 cases with positive sputum culture were subjected. The total frequency of drug resistance and multi-drug resistance were respectively 27.7% and 7.3%. The drug-resistance rate of SM

INH

RFP and EMB were respectively 16.3%

14.0%

10.7% and 4.8%. The drug resistance and multi-drug resistance to RFP and EMB were increased gradually. The factors including retreatment

drug history

and lower annual disposable income per capita may promote the occurrence of multi-drug resistant tuberculosis.     Conclusion    The frequency of drug resistance to tuberculosis in Chongqing is close to the average of whole nation

and

multi-drug resistant rate and the RFP and EMB resistance rates are increasing in recent years. We need to establish and strengthen the continal monitoring on drug resistant tuberculosis in order to prevent and control it.