Objective    To explore the concentration of pregnancy associated plasma-A (PAPP-A)

insulin-like growth factor-1(IGF-1) in indicating the instability of atherosclerotic plaques in patients with non-ST elevation acute coronary syndromes (NSTEACS).     Methods    Totally 65 patients with confirmed NSTEACS were subjected

including 30 non-ST elevation myocardial infarction (NSTEMI) and 35 unstable angina (UA) patients. Another 28 stable angina pectoris verified with vascular stenosis by coronary angiography (CAG) and 30 healthy matched individuals served as control. Serum levels of PAPP-A

C-reactive protein (CRP) and cTnT were measured respectively by enzyme linked immunosorbent assays (ELISA)

rate nephelometry (RN)

and microparticle enzyme immunoassay (MEIA). Correlation analysis was made among different groups.     Results    Serum PAPP-A

IGF-1 and CRP levels in NSTEACS group were significantly increased in comparison to SAP group and control group (P0.01)

with IGF-1 level lower in the SAP group than in the control group

but no difference in the other indexes. In NSTEMI patients

PAPP-A and IGF-1 levels had positive correlation

and these 2 indexes were positive correlated with CRP level

but had no relation with cTnT level.     Conclusion    The concentration of PAPP-A and IGF-1 may reveal the instability of coronary atherosclerotic plaque

and they may be used for diagnosing and predicting NSTEACS risks.