射频消融治疗兔肝VX2肿瘤后消融病灶鬼影细胞的形态变化

王琦; 马宽生; 李廷军; 王铁虎; 欧霞; 王曙光

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射频消融治疗兔肝VX2肿瘤后消融病灶鬼影细胞的形态变化

论著 | 更新时间：2026-01-09

- 射频消融治疗兔肝VX2肿瘤后消融病灶鬼影细胞的形态变化
- Treatment of VX2 hepatic tumor in rabbits with radiofrequency ablation: a study of ghost cells in ablation zones
- 陆军军医大学学报 2008年30卷第12期页码：1173-1175
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  中图分类号： R730.21;R730.56;R735.7
- 纸质出版：2008
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王琦,马宽生,李廷军,王铁虎,欧霞,王曙光.射频消融治疗兔肝VX2肿瘤后消融病灶鬼影细胞的形态变化[J].陆军军医大学学报(原第三军医大学学报),2008,30(12):1173-1175.

　WANG Qi,MA Kuan-sheng,LI Ting-jun,WANG Tie-hu,OU Xia,WANG Shu-guang.Treatment of VX2 hepatic tumor in rabbits with radiofrequency ablation: a study of ghost cells in ablation zones[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(12):1173-1175.
王琦,马宽生,李廷军,王铁虎,欧霞,王曙光.射频消融治疗兔肝VX2肿瘤后消融病灶鬼影细胞的形态变化[J].陆军军医大学学报(原第三军医大学学报),2008,30(12):1173-1175. DOI：

　WANG Qi,MA Kuan-sheng,LI Ting-jun,WANG Tie-hu,OU Xia,WANG Shu-guang.Treatment of VX2 hepatic tumor in rabbits with radiofrequency ablation: a study of ghost cells in ablation zones[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(12):1173-1175. DOI：

摘要

目的观察射频消融治疗兔VX2肿瘤后病灶鬼影细胞存在的时间及不同时间段形态的变化。方法将VX2肿瘤组织块接种于32只新西兰兔肝脏

建立肝脏肿瘤模型，2周后控制肿瘤边缘温度行射频治疗

于治疗结束后0、1、2、4周切取标本，在相邻切面分别行HE染色、NADH活力染色，观察鬼影细胞存在时间以及随时间变化过程。结果射频治疗结束后4周，HE染色下鬼影细胞形态无明显变化

NADH染色显示无活力。结论消融灶鬼影细胞形态至少能保持到治疗后4周，HE染色不能辨别是否是残癌

必须加用NADH活力染色，才能与残癌正确区分。

Abstract

Objective To observe the existing time and the changes in different periods of ghost cells in rabbit hepatic VX2 tumor model after treatment with radiofrequency ablation (RFA). Methods Rabbit hepatoma models were established by implanting VX2 tumor mass into the liver of 32 New Zealand rabbits. RFA was applied to the tumor by controlling the marginal temperature of the tumors. The tissue samples were collected at 0

4 weeks after the treatment. We obtain the HE-stained specimens and NADH vital stained specimens form the close section to observe the the existing time and the changes in different periods of ghost cells. Results No changes was found in the morphous of ghost cells

no sign of vitality was showed in NADH staining 4 weeks after RFA. Conclusion The morphous of ghost cells in ablation zones was to maintain at least 4 weeks after treatment. The remnant tumor can not been indentified by HE but NADH staining.

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