Objective    To investigate the effects of simvastatin on the abatement of the mRNA

protein expression of RhoA and the improvement of the cardiac remodeling and cardiac disfunction after the myocardiac infarction in rats.     Methods    Rats were divided into 3 groups: the control group

the myocardiac infarction group and Simvastatin intervened group. After 8 weeks

cardiac weight index  and hemodynamics were observed

mRNA and protein expression of RhoA in cardiac muscles was measured.     Results    Compared with the control group

the cardiac weight index and the mRNA and protein expression were increased in rats with myocardiac infarction and the hemodynamics was worsened (P0.01) while compared with the group with simvastatin intervention

the cardiac weight index and the hemodynamics were improved and the mRNA and expression of RhoA was decreased   (each P0.01).     Conclusion    Simvastatin abates the mRNA and protein expression of RhoA

which may be one of the mechnisms in the improvement of the cardiac remodeling and cardiac disfunction after acute myocardiac infarction.