Objective    To evaluate the feasibility of heterogenous deproteinated bone modified in repairing the large segmental long bone defect in goat tibia and to investigate its biomechanical changes.     Methods    Eighteen goats were randomly divided into 3 groups (6 goats per group): normal control group

autogenous bone group (AB) and heterogenous deproteinated bone group (HDB). The middle or distal right tibia of the goats in groups AB and HDB was made into 20% periosteum and bone defects and repaired with autogenous bone or heterogenous deproteinated bone. The two broken ends of fractured bone and periosteum were be fixed by half-ring sulcated external fixator. The injured side was subjected to biomechanical examination 24 weeks after surgery

and uninjured side was used as normal control.     Results    The biomechanical examination results showed no significant differences among the three groups 24 weeks after surgery (P0.05).     Conclusion    Heterogenous deproteinated bone composite used in tissue engineering shows similar biomechanics with autogenous bone

so it can be used in clinic trials.