Objective    To explore the correlation of the expressions of angiopoietin-related gene 3 (Angptl3) in the brain

lung

heart

stomach

liver

kidney and adipose tissue in hyperlipidemia rats and the levels of plasma lipid.     Methods    A total of 60 clean-grade male SD rats (200-220 g) were randomly divided into 4 groups: control group (group C); hyperlipidemia group (group H); Diabetic hyperlipidemia group(group D). Real-time PCR (SYBR Green Ⅰ) was used to detect mRNA expressions of Angptl3 in the above mentioned tissues.     Results    It was demonstrated that Angptl3 were expressed in the liver and kidney of every group

but not in other tissues. Its expression was correlated with TG level

and 90% of total angptl3 mRNA were expressed in the liver.     Conclusion    Angptl3 is expressed in the liver and kidney exclusively

which is not changed with the alteration of blood lipid.