HOU Jun,ZHOU Shi-wen.Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(11):1043-1045.
HOU Jun,ZHOU Shi-wen.Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(11):1043-1045.DOI：
Objective To prepare the glycyrrhizic acid solid lipid nanoparticles (GL-SLN). Methods GL-SLN was prepared by conventional rotary-evaporated film-ultrasonication method. Based on the single-factor experiment
GL-SLN was prepared using orthogonal design for optimization of formulation and technology. The obtained GL-SLN was also evaluated. Results GL-SLN had even and regular appearance and the average diameter was 75.8 nm. Zeta potential was -19.7 mV. The drug loading was 8.27% and the entrapment ratio was 91.76%. Conclusion The entrapment ratio of GL-SLN and the stability of GL-SLN prepared by conventional rotary-evaporated film-ultrasonication method are high and good.
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