Objective    To observe the alteration of Foxg1

Foxp2

ER81

Otx1

Foxp1

RORβ

Reelin genes expressing in cerebral cortex in neonatal rat during hypoxic ischemic brain injury (HIBD).     Methods    The HIBD model was established according to Rice method. The expression of each gene in the right cerebral hemisphere was examined by semi-quantitative RT-PCR on 3

rd

7

th

14

th

28

th

and 56

th

day respectively.     Results    Compared with the control

group

the expression level of Foxg1 in HIBD group was lower on 3rd day

higher on 7

th

and 28

th

day (P0.05)

that of Reelin was higher on 3

rd

14

th

and 56

th

day (P0.05)

that of Foxp2 was higher on 7

th

14

th

and 56

th

day (P0.05)

and that of Otx-1 was higher on 7

th

14

th

28

th

and 56

th

day (P0.05). The expression level of Otx-1 was down-regulated in both HIBD and control groups

whereas the expressions of RORβ

Foxp1 and ER81 in this experiment were difficult to determine.     Conclusion    The expression levels of Foxg1

Reelin and Foxp2 were up-regulated

but the expression level of Otx1 was down-regulated

while the alteration tendency of RORβ

Foxp1 and ER81 were unclear in this experiment. The relationship between Foxg1 gene and repair of brain structure will be explored in future.