Objective    To investigate the alteration of inflammatory signal(NF-κB) in aorta of rats with chronic renal failure.     Methods    The animal model was established by partial ligation of renal pedical artery and other side nephrectomy. The mRNA expression of NF-κB and I-κB were detected by RT-PCR

the protein expression of NF-κB was measured by immunohistochemistry

and the activity of NF-κB was examed by  electrophoresis mobility shift assay(EMSA).     Results    Significant increase of the mRNA expression of NF-κB p65 was found in experimental group than in control group（P0.01）

while marked decrease of the mRNA expression of I-κB was noted（P0.01).  The protein expression and activity of NF-κB was also increased significantly(P0.01)

and it is further increased in the course of renal failure progress.  The expression and activity of NF-κB was inhibited significantly by MG-132 treatment.     Conclusion    The inflammatory signal of NF-κB is activated in the pathogenesis of chronic renal failure of rats.