Objective    To compare the resuscitation effect of 6% hydroxyethyl starch (HES) of different molecular weight in normal saline on hemorrhagic shock in rats.     Methods    Hemorrhagic shock model was established in 50 SD rats by 45% hemorrhage

and then they were equally divided into 5 groups. The rats were administered  with HES40/

HES130/

HES200/normal saline

Voluven or Haes. Their mean arterial blood pressure (MAP)

left intraventricular systolic pressure (LVSP)

the maximal change rate of left intraventricular pressure (±dp/dt

max

)

of hemorrhagic shock rat were observed. Meanwhile

the artery blood gas

the survival time and 24-hour survival rate were also observed.     Results    Similar hemodynamic parameters values were obtained in the rats treated with our HES and those with Voluven or Haes. HES130 and HES200 prolonged the survival time of shocked animals in comparison with HES40. Among the 3 types of HES

HES200 had the best effect

which is equivalent to Voluven and Haes.     Conclusion    HES of 3 molecular weights have beneficial effect on hemorrhagic shock

and HES200 exerts best.