Objective    To evaluate the correlation between the polymorphisms of CYP2E1 gene and the susceptibility of lung cancer in Chinese population.     Methods    Polymorphisms of CYP2E1 RsaⅠ/PstⅠ and DraⅠ were detected in 150 patients with lung cancer and 152 healthy controls in Chinese Sichuan Han subjects by PCR-RFLP.  The associations between genetic polymorphisms and susceptibility of lung cancer in Chinese Sichuan Han subjects were analyzed. The interaction among genotype

smoking status and

lung cancer susceptibility were also analyzed.     Results    ① No significant difference in the frequencies of CYP2E1 RsaⅠ/PstⅠ and DraⅠ genotypes were found between the two groups (χ

2

＝3.186，P=0.203 and χ

2

=1.756

P=0.416 respectively); ② Considering the smoking status

more risk of lung cancer was detected in the nonsmokers carried with c1/c1 genotype compared with those mutant genotypes(c1and c2) carriers (OR＝2.453

95%CI=1.140-5.276

P=0.022); ③ More risk of adenocarcinoma was found in the individuals who carried with c1/c1genotype than in those carried with at least one c2 genotypes (OR＝2.440

95%CI=1.235-4.820

P=0.01); ④ No remarkable association between polymorphisms of CYP2E1 DraⅠ genotypes and the susceptibility of lung cancer were found.      Conclusion    ① CYP2E1  c1/c1 genotype is susceptible genotype for lung cancer in Chinese Sichuan Han population in China; ② The polymorphisms of CYP2E1 RsaⅠ/PstⅠ are closely associated with the increased risk for  adenocarcinoma in Chinese Sichuan Han population; ③ No association between CYP2E1 DraⅠ polymorphism and lung cancer risk is found.