Objective To explore the changes of CX3CR1 expressions in monocytes from the patients with different types of coronary heart diseases (CHD).  Methods The expressions of CX3CR1 in monocytes were measured by direct immunofluorescence associated with flow cytometry (FCM) in 54 patients with stable angina pectoris (SAP) confirmed by coronary arteriography

61 patients with acute coronary syndrome (ACS)

20 normal individuals and 24 patients with chest pain syndrome (CPS). Gensini score system was utilized to quantitatively assess the coronary lesion in CHD patients. Finally

the correlation of CX3CR1 levels and Gensini scores was analyzed.  Results CX3CR1 expressions in monocytes from the CHD patients were markedly higher than those in normal individuals (P0.01). CX3CR1 expressions in monocytes from the ASC patients were significantly higher than those in the SAP patients (P0.01). CX3CR1 expressions in monocytes from the CHD patients was positively related to Gensini scores (r=0.913

P0.01).  Conclusion The CHD patients have higher CX3CR1 expressions. The increased degree of CX3CR1expressions is related to the severity of CHD.