ZHANG Guang-jun,LIU Bao-hua,TONG Wei-dong.Expression of ERβ and its isoform in sigmoid colon of female patients with slow transit constipation[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(06):542-545.
ZHANG Guang-jun,LIU Bao-hua,TONG Wei-dong.Expression of ERβ and its isoform in sigmoid colon of female patients with slow transit constipation[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(06):542-545.DOI:
Objective To investigate the expressions of ERβ protein and ERβ isoform mRNA in sigmoid colon of female slow transit constipation patients. Methods RT-PCR and Western blot were used to detect the expression of ERβ protein and ERβ isoform mRNA of 20 patients with STC and 20 age-matched controls. Results ERβ protein and ERβ
1
ERβ
2
and ERβ
5
mRNA were detected in the two groups lower in STC group than that in control group (P0.01),but ERβ
3
and ERβ
4
mRNA were not detectable. Conclusion ERβ is involved in genesis of STC.