Objective To summarize our experience with combined cardiac pacing and betablocker therapy in patients with long-QT syndrome.  Methods Nine patients with long-QT syndrome were treated with Propranolol. Its effectiveness was analyzed during matched periods before and after starting betablocker therapy. If sinus bradycardia

sinus arrest and atrioventricular occurred during the Propranolol treatment

DDD pacemaker were implanted.  Results After initiation of beta-blockers

there was a significant reduction in the rate of cardiac events [(0.86±0.92) to (0.34±0.69) events per patient per year

P0.01] . Numbers of cardiac events per patient were decreased significantly [(3.5±3.6) to (0.9±1.1)

P0.01] after the treatment. Sinus bradycardia in 5 patient and atrioventricular block in 4 patients occurred during the Propranolol treatment were implanted DDD pacemaker . The mean paced rate was (86.0±7.8) beats/min (range

70 to 100 beats/min). After that

QTc in all patient were normal and cardiac events recurred in only one patient.  Conclusion 〗Beta-blockers are associated with a significant reduction in cardiac events in LQTS patients. However

syncope and aborted cardiac arrest continue to occur while patients are on prescribed beta-blockers. Because 8 of 9 patients remain without symptoms with betablocker therapy and continuous pacing

combined therapy appears to provide reasonable

long-term control for this high-risk group.