YU Tai-ping,LI Yong,WANG Tao,JI Ping.Expressions of NF-κB and bcl-xL in draining lymph nodes of oral squamous cell carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(02):150-152.
YU Tai-ping,LI Yong,WANG Tao,JI Ping.Expressions of NF-κB and bcl-xL in draining lymph nodes of oral squamous cell carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(02):150-152.DOI:
ObjectiveTo investigate the expressions and the significance of NF-κB and its target gene bcl-xL in the draining lymph nodes of oral squamous cell carcinoma (OSCC). Methods Thirteen paraffin specimens of draining lymph nodes were divided into inflammatory lymph nodes and metastatic lymph nodes by pathological diagnosis. Immunohistochemistry (S-P method) was used to detect the expressions of NF-κB (p65) and bcl-xL. Results The positive rate of NF-κB (p65) was 30.8% in inflammatory lymph nodes
76.9% in metastatic lymph nodes (P0.01). The positive rate of bcl-xL was 33.3% in inflammatory lymph nodes
73.1% in metastatic lymph nodes (P0.01). Conclusion The progression from inflammatory lymph nodes of OSCC to metastatic ones may involve the expressions of NF-κB and bcl-xL.