Objective To investigate the effects of different ligation position

vena coronaria variation and lidocaine on myocardial infarction size and mortality in rats.   Methods Totally 120 male SD rats were divided into four groups with 30 rats in each group: low ligation with invisible vena coronaria

low ligation with visible vena coronaria

high ligation

and high ligation plus lidocaine.   Results MI was successfully created in 93.0% rats of high ligation groups and in 67.3% rats of low ligation groups. The mortality was 43.3% in rats of high ligation groups

only 13.3% in rats when lidocaine in use.   Conclusion High ligation increases the success rate of rat model of myocardial infarction and the application of lidocaine decreases the mortality of the rat model.