Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the contents of Dopamine and vesicular monoamine transporter-2 (VMAT-2) and synaptophysin (SYN) expressions in striatum of Parkinson’s disease (PD) model mice.   Methods Sixty-five male C57BL/6J mice were randomly divided into 5 experimental groups: control group

PD model group

sham rTMS group

rTMS-1 group exposed to 110% motion threshold

rTMS-2 group exposed to 130% motion threshold

with 13 mice in each group. The model of Parkinsion’s disease of C57BL/6J mice were made by the subcutaneous injection of MPTP solution and then were treated with rTMS for 14 days. The contents of Dopamine in the striatum were measured by high performance liquid chromatography (HPLC-ECD). The VMAT-2 and SYN expressions in striatum were detected by immunohistochemistry and analysed quantitatively by image analysis system.   Results The contents of Dopamine and the positive expressions of VMAT-2 and SYN in rTMS-1 and rTMS-2 groups were significantly lower than those in control group (P0.01)

but higher than those in PD and sham rTMS groups (P0.01). The corrected optical density (COD) of immunoreactive products of VMAT-2 and SYN was lower than that of control group (P0.05)

and significantly higher than that of PD and sham rTMS groups (P0.05). There was no significant difference in COD between rTMS-1 and rTMS-2 groups.   Conclusion rTMS can increase the release of Dopamine and the expressions of VMAT-2 and SYN in striatum of PD model mice

therefore we presume that rTMS may play a role in treating parkinson’s disease by increasing the expressions of VMAT-2  and SYN.