SHI Chun-ying,ZHANG Yi,CHEN Wei,GUO Yan-yan,YANG Tian,YANG Li.Role of lymphoid enhancer factor-1 in the cycle of rat whisker hair follicle[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(01):43-45.
SHI Chun-ying,ZHANG Yi,CHEN Wei,GUO Yan-yan,YANG Tian,YANG Li.Role of lymphoid enhancer factor-1 in the cycle of rat whisker hair follicle[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(01):43-45.DOI：
Objective To study the expression of lymphoid enhancer factor-1 (LEF-1) in the growth cycle of rat whisker hair follicle and explore its role in the process. Methods Cheek skin samples of SD rats at different ages were collected
fixed and sectioned. LEF-1 expression at different periods was detected by immunohistochemistry. Results In anagen
LEF-1 was expressed in the nucleus of bulb and outer root sheath (ORS) of the hair follicle cells
and then with further growth
this nuclear expression pattern gradually converted into cytoplasm expression. In catagen
the staining of LEF-1 became weaken obviously
and disappeared in ORS. In telogen
the expression of LEF-1 appeared in the lateral of bulge again and was strong in IRS. Conclusion LEF-1 may regulate the differentiation of hair shaft and inter root sheath (IRS)
and play an important role in the cycle of hair follicle.
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