ZHONG Shan-chuan,LUO Xue,CHEN Xing-shu,CAI Qi-yan,YAO Zhong-xiang.Expression of transcription factor Engrailed-2 in mouse embryo[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(03):192-194.
ZHONG Shan-chuan,LUO Xue,CHEN Xing-shu,CAI Qi-yan,YAO Zhong-xiang.Expression of transcription factor Engrailed-2 in mouse embryo[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(03):192-194.DOI：
Objective To investigate the expression pattern of the transcription factor Engrailed-2 (EN2) during mouse embryo development. Methods The expression level of EN2 during E8.5 (embryo day 8.5) to E17.5 was detected by Western blot and the mapping of EN2 at different embryo day was detected by immunohistochemistry. Results Western blot analysis showed there were clear straps during E9.5 to E15.5. The expression level of EN2 increased gradually from E9.5 to E13.5
then weakened. Immunohistochemical analysis showed during E9.5 to E15.5
the EN2 protein was detected in mid-hindbrain junction
around the Rathke pouch
in mandibular arch
chiasma opticum
olfactory bulb
discus intervertebrales
dorsolateral muscles and some mesenchymal tissues. Conclusion The EN2 protein maybe involved in differentiation and development of the tissues and the organs mentioned above.
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