Objective To investigate more effective substances or their combination for depleted uranium (DU) decorporation.  Methods We observed the effects of sodium bicarbonate (NaHCO

3

)

4

5-dihydroxybenzene-1

3-disulphonate (Tiron)

diethylenetriaminepenta-methylenephosphonic acid (DTPMP)

dimethylthiourea (DMTU) and their combinations for DU decorporation administered 1 h before DU exposure

immediately or 4 h after DU exposure. Three days after DU exposure

the results of renal function test and pathological examination were compared.  Results Large reduction in urea nitro

gen and serum creatinine was observed when NaHCO

3

combined with DMTU was administered immediately after DU exposure. The most effective treatment tested so far was the combination of NaHCO

3

and DMTU administered after DU exposure at once. However

the efficacy of the tested substances was only partially effective when they were administered 30 min or longer after DU exposure

among which the efficacy of Tiron after prompt and delayed administration was better than the others.  Conclusion The combination of NaHCO

3

and DMTU for DU decorporation is better when administered before or immediately after DU exposure. Tiron for DU decorporation is more effective when administered 4 h after DU exposure.