Objective    To investigate the changes of bone mineral density (BMD) and the relationship of BMD to serum leptin concentrations

body mass index (BMI)

waist hip ratio (WHR)

estradiol(E

2

)

testosterone(T)

biochemical markers of bone turnover as well as other factors in the elderly subjects with Type 2 diabetes mellitus(T2DM).     Methods    BMDs of spine were measured by QCT in patients with T2DM (n=53) and health controls (n=40).The relationship of BMD with serum leptin concentrations

BMI

WHR

E

2

T

bone Gla protein

bone alkaline phosphatase

tartrate resistant acid phosphatase 5b levels

were also analyzed.     Results    The spine BMD values in the T2DM patients were significantly decreased compared with control (P0.05) and the serum leptin levels were significantly higher than controls (P0.05). Serum leptin concentrations was negatively correlated with L

1

BMD and spine mean BMD in the T2DM patients (r=-0.443，r=-0.373；both P0.05). Multiple regression analysis showed that serum leptin concentrations

E

2

and T were independent related factors influencing BMD in T2DM .     Conclusion    The spine BMD in elderly T2DM patients is lower than that of control group. Serum leptin does not have a significant direct influence on bone mass in elderly T2DM patients.