乙酰肝素酶在膀胱移行细胞癌中的表达及与临床特征的关系

鄢俊安; 宋波; 陈志文; 宋彩萍

您当前的位置：

首页 >

文章列表页 >

乙酰肝素酶在膀胱移行细胞癌中的表达及与临床特征的关系

论著 | 更新时间：2026-01-09

- 乙酰肝素酶在膀胱移行细胞癌中的表达及与临床特征的关系
- Heparanase expression in bladder transitional cell carcinoma and its correlation with clinical pathological features
- 陆军军医大学学报 2007年29卷第23期页码：2280-2282
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R345;R730.23;R737.14
- 纸质出版：2007
- 稿件说明：
移动端阅览
鄢俊安,宋波,陈志文,宋彩萍.乙酰肝素酶在膀胱移行细胞癌中的表达及与临床特征的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(23):2280-2282.

　YAN Jun-an,SONG Bo,CHEN Zhi-wen,SONG Cai-ping.Heparanase expression in bladder transitional cell carcinoma and its correlation with clinical pathological features[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(23):2280-2282.
鄢俊安,宋波,陈志文,宋彩萍.乙酰肝素酶在膀胱移行细胞癌中的表达及与临床特征的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(23):2280-2282. DOI：

　YAN Jun-an,SONG Bo,CHEN Zhi-wen,SONG Cai-ping.Heparanase expression in bladder transitional cell carcinoma and its correlation with clinical pathological features[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(23):2280-2282. DOI：

摘要

目的探讨乙酰肝素酶（heparanase，HPA）在膀胱移行细胞癌中的表达及与肿瘤临床病理特征的关系。方法应用逆转录-聚合酶链反应（RT-PCR）及免疫组织化学方法检测68例膀胱移行细胞癌、24例癌旁组织中HPA mRNA的水平及蛋白表达定位，并结合患者临床病理指标及预后进行分析。结果 68例膀胱移行细胞癌组织中HPA mRNA检出阳性41例（60.3%），24例癌旁组织中HPA mRNA检出阳性1例（4.2%），两组间差异有统计学意义（P0.01），HPA mRNA的表达在膀胱移行细胞癌不同病理分级、临床分期及淋巴结转移与否分组中显著不同（P0.01）。免疫组化结果显示，HPA定位于细胞质及细胞核，阳性率为77.9%（53例），在膀胱移行细胞癌淋巴结转移与否分组中显著不同（P001）。结论 HPA在膀胱移行细胞癌的生长浸润、侵袭转移中可能发挥重要作用。

Abstract

Objective To explore the expression of heparanase (HPA) and its correlation with the clinical pathological features and angiogenesis in bladder transitional cell carcinoma. Methods HPA mRNA level was detected with RT-PCR and its protein level was determined by immunohistochemical staining in 68 cases of bladder cancer and 24 cases of adjacent tissues of bladder cancer. Results The positive rate of HPA mRNA was 60.3% (41/68) in bladder cancer

4.2% (1/24) in the adjacent tissues of bladder cancer. The expression of HPA mRNA had statistically significant correlation with pathological stage

clinical staging and lymphonode metastasis (P0.01). Immunohistochemistry showed HPA located in the cytoplasm and nucleus of bladder cancer and its positive rate was 77.9% (53/68). In addition

HPA protein levels were statistically different in the cases with and without lymphonode metastasis (P0.01). Conclusion HPA may play an important role in the growth

invasion and metastasis of bladder cancer. HPA was a useful marker of the biological behavior of bladder cancer and an independent prognosis factor of bladder cancer.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

COX-2和EGFR在膀胱移行细胞癌组织中的表达及其相关性研究

联合检测P504s和Claudin-4在前列腺癌中的表达及其在预后评估中的价值

丙酮酸脱氢酶激酶4在结肠癌组织中的表达及临床意义

S100A4、SEPT7在儿童神经胶质瘤的表达特点及临床意义

胰腺癌组织中硫酸软骨素蛋白多糖4的表达及其临床意义