抑制Kit信号通路对豚鼠膀胱间质细胞增殖及自主节律性运动的影响

唐仕明; 何大朋; 王忠; 辜福贤; 王明荣

您当前的位置：

首页 >

文章列表页 >

抑制Kit信号通路对豚鼠膀胱间质细胞增殖及自主节律性运动的影响

论著 | 更新时间：2026-01-09

- 抑制Kit信号通路对豚鼠膀胱间质细胞增殖及自主节律性运动的影响
- Effects of inhibiting Kit signal pathway on proliferation and spontaneous rhythmic motility of interstitial cells in bladder of guinea pigs
- 陆军军医大学学报 2007年29卷第23期页码：2264-2266
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R322.62;R329.28
- 纸质出版：2007
- 稿件说明：
移动端阅览
唐仕明,何大朋,王忠,辜福贤,王明荣.抑制Kit信号通路对豚鼠膀胱间质细胞增殖及自主节律性运动的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(23):2264-2266.

　TANG Shi-ming,HE Da-peng,WANG Zhong,GU Fu-xian,WANG Ming-rong.Effects of inhibiting Kit signal pathway on proliferation and spontaneous rhythmic motility of interstitial cells in bladder of guinea pigs[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(23):2264-2266.
唐仕明,何大朋,王忠,辜福贤,王明荣.抑制Kit信号通路对豚鼠膀胱间质细胞增殖及自主节律性运动的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(23):2264-2266. DOI：

　TANG Shi-ming,HE Da-peng,WANG Zhong,GU Fu-xian,WANG Ming-rong.Effects of inhibiting Kit signal pathway on proliferation and spontaneous rhythmic motility of interstitial cells in bladder of guinea pigs[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(23):2264-2266. DOI：

摘要

目的探讨抑制Kit表达对豚鼠膀胱间质细胞(interstitial cells

ICs)增殖及自主节律性运动的影响。方法成年豚鼠分别予伊马替尼灌胃20 d和40 d，免疫荧光、Western blot和体外灌流观察间质细胞形态和功能的变化。结果正常豚鼠膀胱壁内可见较多的间质细胞，用药20 d和40 d后，细胞数量逐渐减少，Kit蛋白的表达逐渐降低，同时，膀胱的自主节律性运动受到抑制。结论膀胱内含间质细胞，这些细胞可能是膀胱运动的起搏细胞，其细胞表面表达的Kit蛋白对间质细胞的存活和功能维持都具有重要的作用。

Abstract

Objective To investigate the role of Kit signal pathway in the proliferation and spontaneous rhythmic motility of interstitial cells (ICs) in the bladder of guinea pigs. Methods Fourteen Guinea pigs aged 45-60 days were administered with Imatinib intragastrically for 20 and 40 days. Three were fed on normal saline as control. The morph and number of ICs were observed by immunofluorescence

Kit protein expression was detected by Western blot and spontaneous rhythmic motility of bladder were investigated in in vitro organ bath. Results Quite a few ICs were observed in the bladder of controls. After administration of Imatinib

the amount of ICs and the expression of Kit protein decreased gradually

and the spontaneous rhythmic contraction weakened. Conclusion ICs might be the pacemaker of bladder in guinea pigs. Kit protein might play an important role in the survival and functional maintenance of ICs.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

川楝素通过下调c-kit表达抑制GIST-T1细胞增殖并促进其凋亡

靶向抗ICAM-1的载伊马替尼和液态氟碳脂质体对内毒素诱导的急性肺损伤/急性呼吸窘迫综合征模型小鼠的治疗研究

敲低肌切蛋白可抑制胃肠道间质瘤细胞的增殖能力

Kit信号通路调控成年小鼠Cajal间质细胞的表型改变