Objective  To observe the effect of glycyrrhizin (Meineng) on liver fibrosis in unmatured Wistar rats for the prevention and therapy of children’s diseases.   Methods  The liver fibrosis model in rats aged 22-23 days was established by intraperitoneal injection of the mixture of CCl

4

and peanut oil. Glycyrrhizin was used for prevention and treatment of liver fibrosis. Group A: after 2-

4-

6-

8-week liver fibrosis establishment

the rats received glycyrrhizin till the experiment ended. Group B: Accompanying the rat model establishment

glycyrrhizin was used

and the rats were sacrificed at 2

nd

4

th

6

th

8

th

week after experiment started. Group C: Liver fibrosis establishment only. At the end of experiment

the morphological and pathological changes of liver tissues were observed in all rats.   Results  The morphologic

al and pathological changes of the liver tissues in group A were much less than that in groups B and C. The therapeutic effect got better as treatment period prolonged.   Conclusion  Glycyrrhizin can efficaciously prevent and treat liver fibrosis in unmatured Wistar rats.