全乳大切片观察新辅助化疗后乳腺癌浸润性生长特征变化

张毅; 周艳; 郭美琴; 郭德玉; 封传悦; 姜军

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全乳大切片观察新辅助化疗后乳腺癌浸润性生长特征变化

论著 | 更新时间：2026-01-09

- 全乳大切片观察新辅助化疗后乳腺癌浸润性生长特征变化
- Infiltrating characteristics of breast cancer after neoadjuvant chemotherapy: whole breast serial subsection observation
- 陆军军医大学学报 2007年29卷第21期页码：2083-2085
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  中图分类号： R446.8;R730.23;R737.9
- 纸质出版：2007
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张毅,周艳,郭美琴,郭德玉,封传悦,姜军.全乳大切片观察新辅助化疗后乳腺癌浸润性生长特征变化[J].陆军军医大学学报(原第三军医大学学报),2007,29(21):2083-2085.

　ZHANG Yi,ZHOU Yan,GUO Mei-qin,GUO De-yu,FENG Chuan-yue,JIANG Jun.Infiltrating characteristics of breast cancer after neoadjuvant chemotherapy: whole breast serial subsection observation[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(21):2083-2085.
张毅,周艳,郭美琴,郭德玉,封传悦,姜军.全乳大切片观察新辅助化疗后乳腺癌浸润性生长特征变化[J].陆军军医大学学报(原第三军医大学学报),2007,29(21):2083-2085. DOI：

　ZHANG Yi,ZHOU Yan,GUO Mei-qin,GUO De-yu,FENG Chuan-yue,JIANG Jun.Infiltrating characteristics of breast cancer after neoadjuvant chemotherapy: whole breast serial subsection observation[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(21):2083-2085. DOI：

摘要

目的探讨乳腺癌的浸润特征及新辅助化疗对乳腺癌浸润特点的改变。方法采用全乳大切片技术对比研究病理分期为Ⅰ~Ⅲ期93例行术前化疗与31例未行术前化疗乳腺癌的浸润特征。结果对照组皮肤皮下浸润阳性35.5%，发生大导管浸润者25.8%，对肿瘤周围血管浸润者38.7%，肿瘤微血管计数(MVD)17.2±9.5;新辅助化疗后皮肤皮下浸润阳性9.7%

大导管浸润阳性8.6%

肿瘤周围血管浸润阳性11.8%

MVD 8.0±4.4

各项指标均明显低于对照组（P0.05）。结论新辅助化疗显著减轻乳腺癌对周围组织的浸润，可增加保乳机会。

Abstract

Objective To study the infiltrating characteristics of breast cancer and the influence of neoadjuvant chemotherapy to it. Methods The whole breast subserial section technique was used to study infitrating characteristics in 93 cases of breast cancer with neoadjuvant chemotherapy and 31 cases without from June 2005 to August 2006. Results In those without neoadjuvant chemotherapy

skin-subcutaneous tissue involvement was 35.5%

big duct involvement 25.8%

invasion to blood vessel around tumor 38.7% and tumor microvascular density (MVD) was (17.2±9.5). In those with neoadujvant chemotherapy

skin-subcutaneous tissue involvement was 9.7%

big duct involvement 8.6%

blood vessel invasion 11.8% and tumor MVD was (8±4.4). Every index after neoadjuvant chemotherapy was significantly lower (P0.05). Conclusion Neoadjuvant chemotherapy can abate infiltration to peripheral tissues of breast cancer and raise the chance of breast conserving therapy.

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