Objective    To study the constituent features and changing tendency of gestational trophoblastic neoplasia in Guangxi province and explore high risk factors.     Methods    Clinical data of 1075 patients with gestational trophoblastic neoplasia treated at 23 hospitals in our province from 1985 to 2004 were subjected and retrospectively analyzed. The data were divided into 4 time-periods (1985-1989

1990-1994

1995-1999

and 2000-2004). The obtained outcomes were compared among those 4 periods.     Results    The constituent ratio of the neoplasia in all gynecologic cancers was decreased from 30.69%（1985-1989）to 7.34% (2000-2004)

and the sequence was fallen from No. 2 to No. 4. Most patients were 20 to 39 years old

and 55.44% of cases were from countryside. There was no difference between urban and countryside patients. Most of them were advanced gestational trophoblastic neoplasia from 1980s to 1990s

but 53.5% were stage Ⅰand Ⅱ since 2000. Chemotherapy was carried out in most cases.     Conclusion    The sequence of gestational trophoblastic neoplasia in all gynecologic cancers in Guangxi province has decreased from No. 2 to No. 4 since 1980s with a tendency of diminishing. It may be closely related with change of reproductive views

implementation of family planning

and increased early diagnosis rate.