血清c-PSA及 C/T在提高前列腺癌诊断特异性中的探讨

胡望平; 冯福英; 叶桂云; 肖少林; 章宏斌; 王海林; 郑苗

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血清c-PSA及 C/T在提高前列腺癌诊断特异性中的探讨

论著 | 更新时间：2026-01-09

- 血清c-PSA及 C/T在提高前列腺癌诊断特异性中的探讨
- Serum complexed-PSA and ratio of complexed/total PSA to improve diagnostic specificity on identifying prostate cancer
- 陆军军医大学学报 2007年29卷第18期页码：1815-1817
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  中图分类号： R392.11;R730.43;R737.25
- 纸质出版：2007
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胡望平,冯福英,叶桂云,肖少林,章宏斌,王海林,郑苗.血清c-PSA及 C/T在提高前列腺癌诊断特异性中的探讨[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1815-1817.

　HU Wang-Ping,FENG Fu-ying,YE Gui-yun,XIAO Shao-lin,ZHANG Hong-bin,WANG Hai-lin,ZHENG Miao.Serum complexed-PSA and ratio of complexed/total PSA to improve diagnostic specificity on identifying prostate cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1815-1817.
胡望平,冯福英,叶桂云,肖少林,章宏斌,王海林,郑苗.血清c-PSA及 C/T在提高前列腺癌诊断特异性中的探讨[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1815-1817. DOI：

　HU Wang-Ping,FENG Fu-ying,YE Gui-yun,XIAO Shao-lin,ZHANG Hong-bin,WANG Hai-lin,ZHENG Miao.Serum complexed-PSA and ratio of complexed/total PSA to improve diagnostic specificity on identifying prostate cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1815-1817. DOI：

摘要

目的研究复合前列腺特异性抗原（c-PSA）及相关指标在鉴别诊断前列腺癌和良性前列腺增生中的应用价值，提高前列腺癌诊断特异性。方法分析了70例男性，经B超、病理诊断证实18例为前列腺癌(PCa)，27例为良性前列腺增生(BPH)，25例为正常对照组。Bayer ACS:180化学发光法测得c-PSA、t-PSA，计算c-PSA/t-PSA值(C/T)。结果 t-检验比较PCa和BPH组的c-PSA、t-PSA、C/T和Age值，前两者有显著性差异（P0.01），后两者无显著性差异（P0.05）。分别计算PCa和BPH组的c-PSA、t-PSA的直线相关系数r，PCa组r=0.981 2

PCa组回归方程为c-PSA=0.935 4×tPSA-2.91

高度相关。BPH组r=0.410 9。在100％敏感性时，c-PSA 3.75 μg/L、t-PSA 4.0 μg/L、C/T=0.65、c-PSA 7.5 μg/L加（C/T=0.65）的特异性分别为42.3％、38.5％、36.5％、75.0％。结论前列腺癌比BPH的c-PSA 和t-PSA相关度高。在保持灵敏度100%时，若结合c-PSA 7.5 μg/L加（C/T=0.65）指标，将明显提高特异性到75.0% 。

Abstract

Objective To evaluate complexed prostate-specific antigen (c-PSA) in differential diagnosis of prostate cancer and benign prostate hyperplasia (BPH). Methods Totally 60 men were subjected

including 18 cases of prostate cancer (PCa)

27 cases of BPH

and 25 normal individuals (control group). All subjects were diagnosed by ultrasonography and pathological methods. Serum c-PSA and total-PSA (t-PSA) were measured by automated chemiluminescence system Bayer ACS:180. The ratio of c-PSA to t-PSA (C/T) was calculated respectively. Results Student t test indicated that significant difference was seen in c-PSA and t-PSA between BPH and PCa

but no difference in C/T and age. There was significant close correlation of c-PSA and t-PSA in PCa group. But no relation of these indexes was seen in BPH group. As for 100％ sensitivity

the specificity for c-PSA 3.75 μg/L

t-PSA 4.0 μg/L

C/T=0.65

c-PSA 7.5 μg/L+(C/T=0.65) were 42.3％

38.5％

36.5％ and 75.0％ respectively. Conclusion c-PSA and t-PSA have higher relativity in Pca group than in BPH group. As for the sensitivity 100%

it can be apparently improve to 75.0% when c-PSA 7.5 μg/L and C/T radio=0.6 5 are integrated.

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