WANG Xiu-qin,LUO Xiang-dong,WU Su-hua.Hemostatic effects and safety evaluation of QuGouCao[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(14):1419-1421.
WANG Xiu-qin,LUO Xiang-dong,WU Su-hua.Hemostatic effects and safety evaluation of QuGouCao[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(14):1419-1421.DOI：
Objective To investigate the hemostatic effects and safety of the QuGouCao chloroform-water extract. Methods The hemostatic property of the extract was studied by applying the extract soaked gauze to the local wound surface of skin
liver and femoral artery in rabbits. LD
50
test in Kuming mice was performed and the tissues of liver and kidney were collected for routine histochemical examination. The skin stimulus in rabbits and the sensitivity test in guinea pigs were conducted. Results The hemostatic time of wounds was obviously shorter (P0.01) than that of blank group control. LD
50
was 483.08 mg/kg. The liver and kidney of toxicated mice were normal when the extract less than 300 mg/kg. 10% QuGouCao chloroform-water extract had no stimul
ation effect on the intact skin or damaged skin as well as caused no allergic or toxic reaction. Conclusion The QuGouCao chloroform-water extract has good hemostatic effect on the local wound surfaces. It is of low toxicity
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